产品货号：
GS4903
中文名称：
重组人MIC-B
英文名称：
Recombinant Human MHC Class I Polypeptide-Related Sequence B
产品规格：
10μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 32.8kDa,a single non-glycosylated polypeptide chain containing 287 amino acids.
储存条件：冷冻（-20℃）
概述
MIC-B(MHC class I chain-related gene B)is a single-pass type I member protein.It is widely expressed in many,but not all,epithelial tumors of lung,breast,kidney,ovary,prostate and colon.In addition to this,it is produced by hepatocellular carcinomas,which is only in tumor cells but not in surrounding non-cancerous tissue and can be induced by bacterial and viral infections.MIC-B shares 85%amino acid identity with MIC-A and they are distantly related to the MHC class I proteins.Because they possess three extracellular Ig-like domains,but unlike classical MHC class I molecules,they do not form a heterodimer with beta2 microglobulin,but bind as a monomer to a KLRK1/NKG2D that is an activating receptor expressed on NK cells,NKT cells,γδ T cells,and CD8+ αβ T cells.Recognition of MIC-B by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells.MIC-B recognition plays an important role in tumor surveillance,viral infections,and autoimmune diseases.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人MIC-B，MIC-B, Human
储存条件：冷冻（-20℃）
概述
MIC-B(MHC class I chain-related gene B)is a single-pass type I member protein.It is widely expressed in many,but not all,epithelial tumors of lung,breast,kidney,ovary,prostate and colon.In addition to this,it is produced by hepatocellular carcinomas,which is only in tumor cells but not in surrounding non-cancerous tissue and can be induced by bacterial and viral infections.MIC-B shares 85%amino acid identity with MIC-A and they are distantly related to the MHC class I proteins.Because they possess three extracellular Ig-like domains,but unlike classical MHC class I molecules,they do not form a heterodimer with beta2 microglobulin,but bind as a monomer to a KLRK1/NKG2D that is an activating receptor expressed on NK cells,NKT cells,γδ T cells,and CD8+ αβ T cells.Recognition of MIC-B by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells.MIC-B recognition plays an important role in tumor surveillance,viral infections,and autoimmune diseases.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The specific activity is determined by binding MICB antibody in ELISA. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in 20mMTris,150 mM NaCl,pH 8.0. |
| 内毒素 | Less than 1 EU/μg of rHuMIC-B as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | AEPHSLRYNL MVLSQDESVQ SGFLAEGHLD GQPFLRYDRQ KRRAKPQGQW AEDVLGAKTW DTETEDLTEN GQDLRRTLTH IKDQKGGLHS LQEIRVCEIH EDSSTRGSRH FYYDGELFLS QNLETQESTV PQSSRAQTLA MNVTNFWKED AMKTKTHYRA MQADCLQKLQ RYLKSGVAIR RTVPPMVNVT CSEVSEGNIT VTCRASSFYP RNITLTWRQD GVSLSHNTQQ WG |
相关搜索：重组人MIC-B，MIC-B, Human